The attack happened in Kaduna, scene of many sectarian attacks.
The blast was caused by at least one vehicle being driven towards the church loaded with explosives, witnesses said.
No-one has claimed responsibility, but Islamist group Boko Haram has been involved in several recent attacks in the area.
The attack happened in the Malali neighbourhood of the city about 8:45am National Emergency Management Agency spokesman Yushua Shuaib told AP news agency initial reports suggested the attack was by a suicide bomber.
The church was surrounded by soldiers and police after the blast, and ambulances took the injured to hospital.
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